State health officials Friday confirmed the first human death from West Nile virus in Colorado this year.

The Colorado Department of Public Health and Environment said a Lafayette resident has died from the virus.

“We are deeply saddened to confirm the first West Nile virus-related death in our state this year,” Dr. Ned Calonge, Chief Medical Officer at CDPHE, said in a news release. “This tragic loss underscores the serious nature of this virus and why personal prevention is so vital.”

State health officials said there are nine other known cases this year across eight counties, but so far no other deaths.

West Nile virus usually spreads via mosquito bites, with symptoms appearing three to 14 days after being bitten. Infected mosquitos have been found in half of the 16 counties tested this year, including Adams, Arapahoe, Boulder, Broomfield, Denver, Jefferson, Larimer and Weld counties. 

“I cannot stress enough the importance of taking simple, effective steps — like using repellant and draining standing water — to protect yourself and your loved ones from West Nile virus infections,” Calonge said.

Adams County reports first two human cases of West Nile virus for 2025

West Nile Virus symptoms typically include:

• Fever

• Severe fatigue

• Headache

• Body aches

• Skin rash

• Swollen lymph nodes

State health officials said people over 60 or who have certain health conditions are at greater risk if contracting the virus.

Best ways to protect yourself from West Nile virus

According to CDPHE

• Use insect repellent with DEET, picaridin, I3535, oil of lemon eucalyptus or para-menthane-diol

• Limit time outside at dawn and dusk when mosquitos are most active

• Cover skin in areas when mosquitos are active

• Remove standing water from our yard and gutters weekly

• Install or repair window and door screens