Two people are dead and seven others were injured in multiple crashes and a hit-and-run across the metro area overnight, including a wrong-way crash on Interstate 25.

The largest crash occurred near 8th Avenue and Interstate 25 It involved five vehicles. Five people went to the hospital with minor injuries. The Denver Police Department announced the crash around 5 a.m. on Twitter.

Police said an unidentified woman drove north in the southbound lanes of the interstate. Oncoming vehicles crashed as they tried avoid her.

The woman suffered serious injuries. She was cited for driving under the influence and reckless driving causing injuries, police said.

Around the same time, officers were dispatched just north of the large crash to the Alameda Street exit after reports of a hit and run.

Police have released limited information regarding this incident, but said one victim was transported to the hospital with injuries. Authorities did not release the status of the individual.

No arrests or information about a possible suspect had been released as of 10:40 a.m.

Police responded to a report of another crash further south on the interstate at the Belleview Avenue exit in the Denver Tech Center around 11 p.m., police said.

When officers arrived, they located a single vehicle with a man inside. He was pronounced dead on-scene, according to a spokeswoman for the department.

Police said the man was traveling at a high rate of speed when he appears to have lost control and collided into the median. It is unknown if drugs or alcohol played a role in the crash, according to the spokeswoman.

In Aurora, police responded to a report of a crash at the intersection of East Iliff Avenue and South Havana Street around 12:15 a.m., after reports of a multi-vehicle accident, according to a release from the Aurora Police Department.

Officers located two vehicles at the intersection and found a 25-year-old man injured and unresponsive in a minivan. The driver of the other vehicle, a Jeep, was uninjured, police said.

The driver of the minivan was transported to a local hospital where he later died as a result of his injuries, police said.

An initial investigation of the incident indicates the minivan was headed east along East Iliff Avenue and failed to stop at a red light, striking the Jeep, police said.

It is unknown if drugs, alcohol or speed played a factor in the crash.

Police have not identified the two people who died overnight and said they’d be identified at a later date.